CDC25C Gene Summary [Human]
This gene encodes a conserved protein that plays a key role in the regulation of cell division. The encoded protein directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It also suppresses p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Dec 2015]
Details
| Type | Protein Coding |
| Official Symbol | CDC25C |
| Official Name | cell division cycle 25C [Source:HGNC Symbol;Acc:HGNC:1727] |
| Ensembl ID | ENSG00000158402 |
| Bio databases IDs | |
| Aliases | cell division cycle 25C, protein phosphatase 1, regulatory subunit 60, CDC25 homolog C (S. pombe), M-phase inducer phosphatase 3 |
| Synonyms | CDC25, cdc25c-64, cell division cycle 25C, PPP1R60 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CDC25C often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- regulatory domain
- protein kinase binding
- protein-tyrosine-phoshatase
- Cdc2 phosphorylation site
- catalytic domain
- Rhodanese Homology Domain
- WW domain binding
- protein binding
- Rhodanese-like domain
- Chk1 phosphorylation site
- RHOD
- phosphorylation site
- protein phosphatase
- phosphatase
Pathways
Biological processes and signaling networks where the CDC25C gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- liver cancer
- breast carcinoma
- vulva cancer
- organismal death
- prostate cancer
- schizophrenia
- atrial fibrillation
- hepatitis B virus-related hepatocellular carcinoma
- chronic lymphocytic leukemia
role in cell
- apoptosis
- proliferation
- expression in
- activation in
- S phase
- G2/M phase
- cell death
- mitosis
- G1/S phase transition
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- perinuclear region
- centrosome
- cytosol
- mitochondrial intermembrane space
- nucleoplasm
- spindle pole
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CDC25C gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell proliferation
- cell division
- G2/M transition of mitotic cell cycle
- regulation of mitosis
- spermatogenesis
- positive regulation of G2/M transition of mitotic cell cycle
- regulation of cyclin-dependent protein kinase activity
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrial intermembrane space
- perinuclear region of cytoplasm
- cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- phosphoprotein phosphatase activity
- protein binding
- protein tyrosine phosphatase activity
- WW domain binding