LRRC32 Gene Summary [Human]
This gene encodes a type I membrane protein which contains 20 leucine-rich repeats. Alterations in the chromosomal region 11q13-11q14 are involved in several pathologies. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | LRRC32 |
| Official Name | leucine rich repeat containing 32 [Source:HGNC Symbol;Acc:HGNC:4161] |
| Ensembl ID | ENSG00000137507 |
| Bio databases IDs | |
| Aliases | leucine rich repeat containing 32 |
| Synonyms | AI426318, CPPRDD, D11S833E, D11S833Eh, D7H11S833E, EG434215, GARP, leucine rich repeat containing 32 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LRRC32 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein phosphatase 1 regulatory subunit 42
- Leucine rich repeat
- protein binding
- Leucine rich repeat N-terminal domain
- TGFbeta binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- neoplasia
- breast cancer
- urogenital cancer
- epithelial cancer
- epithelial neoplasia
- lung cancer
- metastasis
- Crohn disease
- developmental delay, cleft palate and proliferative retinopathy
role in cell
- production in
- expression in
- proliferation
- phosphorylation in
- quantity
- apoptosis
- activation
- molecular cleavage in
- expansion
- proliferative capacity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- intracellular space
- cellular membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LRRC32 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of gene expression
- establishment of protein localization in extracellular region
- transforming growth factor beta receptor signaling pathway
- negative regulation of activated T cell proliferation
- negative regulation of cytokine production
Cellular Component
Where in the cell the gene product is active
- extracellular space
- external side of plasma membrane
- extracellular matrix
- plasma membrane
- cell surface
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- transforming growth factor beta binding
- protein binding