SLC39A10 Gene Summary [Human]
Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A10 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003 [PubMed 12659941]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | SLC39A10 |
| Official Name | solute carrier family 39 member 10 [Source:HGNC Symbol;Acc:HGNC:20861] |
| Ensembl ID | ENSG00000196950 |
| Bio databases IDs | |
| Aliases | solute carrier family 39 member 10 |
| Synonyms | 2900042E17Rik, 5430433I10, KIAA1265, LOC107985971, LZT-Hs2, mKIAA1265, solute carrier family 39 member 10, solute carrier family 39 (zinc transporter), member 10, ZIP10 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SLC39A10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein tyrosine phosphatase activator
- ZIP Zinc transporter
- protein binding
- zinc ion transporter
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- preeclampsia
- gastric adenocarcinoma
- gastric epithelial cancer
- organismal death
- liver damage
- adenoma formation
- aldosterone producing adrenocortical adenoma
role in cell
- apoptosis
- proliferation
- phosphorylation in
- quantity
- activation in
- colony formation by
- hematopoiesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Plasma Membrane
- apical membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SLC39A10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of B cell receptor signaling pathway
- negative regulation of B cell apoptotic process
- cellular zinc ion homeostasis
- zinc ion import
- positive regulation of B cell proliferation
- epithelial to mesenchymal transition
- zinc ion transmembrane transport
- cellular cation homeostasis
- bicarbonate transport
Cellular Component
Where in the cell the gene product is active
- apical plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- zinc ion transmembrane transporter activity