Lrrc32 Gene Summary [Mouse]
Enables transforming growth factor beta binding activity. Involved in establishment of protein localization to extracellular region and secondary palate development. Acts upstream of or within negative regulation of activated T cell proliferation; negative regulation of cytokine production; and positive regulation of gene expression. Predicted to be located in cell surface and nucleoplasm. Predicted to be active in extracellular matrix; extracellular space; and plasma membrane. Is expressed in several structures, including genitourinary system; jaw; lung; sensory organ; and skeletal muscle. Orthologous to human LRRC32 (leucine rich repeat containing 32). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lrrc32 |
| Official Name | leucine rich repeat containing 32 [Source:MGI Symbol;Acc:MGI:93882] |
| Ensembl ID | ENSMUSG00000090958 |
| Bio databases IDs | |
| Aliases | leucine rich repeat containing 32 |
| Synonyms | AI426318, CPPRDD, D11S833E, D11S833Eh, D7H11S833E, EG434215, GARP, leucine rich repeat containing 32 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lrrc32 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein phosphatase 1 regulatory subunit 42
- Leucine rich repeat
- protein binding
- Leucine rich repeat N-terminal domain
- TGFbeta binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- neoplasia
- breast cancer
- urogenital cancer
- epithelial cancer
- epithelial neoplasia
- lung cancer
- metastasis
- Crohn disease
- developmental delay, cleft palate and proliferative retinopathy
role in cell
- production in
- expression in
- proliferation
- phosphorylation in
- quantity
- apoptosis
- activation
- molecular cleavage in
- expansion
- proliferative capacity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- intracellular space
- cellular membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lrrc32 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of gene expression
- establishment of protein localization in extracellular region
- transforming growth factor beta receptor signaling pathway
- negative regulation of activated T cell proliferation
- negative regulation of cytokine production
Cellular Component
Where in the cell the gene product is active
- extracellular space
- external side of plasma membrane
- extracellular matrix
- plasma membrane
- cell surface
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- transforming growth factor beta binding
- protein binding