SULF1 Gene Summary [Human]
This gene encodes an extracellular heparan sulfate endosulfatase. The encoded enzyme selectively removes 6-O-sulfate groups from heparan sulfate chains of heparan sulfate proteoglycans (HSPGs). The enzyme is secreted through the Golgi and is subsequently localized to the cell surface. The expression of this gene may be down-regulated in several types of cancer, including hepatocellular (HCC), ovarian and breast cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Details
| Type | Protein Coding |
| Official Symbol | SULF1 |
| Official Name | sulfatase 1 [Source:HGNC Symbol;Acc:HGNC:20391] |
| Ensembl ID | ENSG00000137573 |
| Bio databases IDs | |
| Aliases | sulfatase 1, Extracellular sulfatase Sulf-1 |
| Synonyms | KIAA1077, LOC171396, mKIAA1077, MSulf-1, RSulfFP1, sulfatase 1, sulph1, sulphatase 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SULF1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- alkaline phosphatases and sulfatases
- N-acetylglucosamine-6-sulfatase
- Sulfatase
- enzyme
- Sulfatase protein
- arylsulfatase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-small cell lung cancer
- neoplasia
- dyspnea
- idiopathic pulmonary fibrosis
- growth failure
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
- diabetic nephropathy
- endometriosis
- lung adenocarcinoma
role in cell
- expression in
- signaling in
- phosphorylation in
- motility
- apoptosis
- growth
- cell death
- invasion
- proliferation
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell surface
- Extracellular Space
- Plasma Membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- Golgi stacks
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SULF1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of angiogenesis
- negative regulation of fibroblast growth factor receptor signaling pathway
- regulation of fibroblast growth factor receptor signaling pathway
- glial cell-derived neurotrophic factor receptor signaling pathway
- glomerular filtration
- innervation
- chondrocyte development
- embryonic skeletal system development
- negative regulation of prostatic bud formation
- bone development
- glomerular basement membrane development
- positive regulation of BMP signaling pathway
- vascular endothelial growth factor receptor signaling pathway
- kidney development
- apoptotic process
- negative regulation of endothelial cell proliferation
- esophagus smooth muscle contraction
- positive regulation of Wnt receptor signaling pathway
- heparan sulfate proteoglycan metabolic process
- negative regulation of cell migration
- cartilage development
- positive regulation vascular endothelial growth factor production
Cellular Component
Where in the cell the gene product is active
- extracellular space
- membrane raft
- Golgi apparatus
- endoplasmic reticulum
- Golgi stack
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- glycosaminoglycan binding
- calcium ion binding
- arylsulfatase activity
- N-acetylglucosamine-6-sulfatase activity