NDST4 Gene Summary [Human]
Predicted to enable [heparan sulfate]-glucosamine N-sulfotransferase activity and deacetylase activity. Predicted to be involved in heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process. Predicted to be located in Golgi membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | NDST4 |
| Official Name | N-deacetylase and N-sulfotransferase 4 [Source:HGNC Symbol;Acc:HGNC:20779] |
| Ensembl ID | ENSG00000138653 |
| Bio databases IDs | |
| Aliases | N-deacetylase and N-sulfotransferase 4 |
| Synonyms | 4930439H17Rik, N-deacetylase and N-sulfotransferase 4, N-deacetylase and N-sulphotransferase 4, N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4, N-deacetylase/N-sulphotransferase (heparin glucosaminyl) 4, N-HSST, N-HSST 4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NDST4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- carboxylic ester hydrolase
- sulfotransferase
- [heparan sulfate]-glucosamine N-sulfotransferase
- N-acetylglucosamine deacetylase
- Sulfotransferase domain
- enzyme
- deacetylase
- Sulfotransferase family
- heparan sulfate-N-deacetylase
Pathways
Biological processes and signaling networks where the NDST4 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NDST4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process
- heparin biosynthetic process
Cellular Component
Where in the cell the gene product is active
- Golgi apparatus
- Golgi membrane
Molecular Function
What the gene product does at the molecular level
- [heparan sulfate]-glucosamine N-sulfotransferase activity
- N-acetylglucosamine deacetylase activity
- deacetylase activity