CDKL2 Gene Summary [Human]
This gene product is a member of a large family of CDC2-related serine/threonine protein kinases. It accumulates primarily in the cytoplasm, with lower levels in the nucleus. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | CDKL2 |
| Official Name | cyclin dependent kinase like 2 [Source:HGNC Symbol;Acc:HGNC:1782] |
| Ensembl ID | ENSG00000138769 |
| Bio databases IDs | |
| Aliases | cyclin dependent kinase like 2 |
| Synonyms | 5330436L21Rik, cyclin dependent kinase like 2, KKIAMRE, Kkm, P56 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CDKL2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- Protein Kinases, catalytic domain
- Protein tyrosine and serine/threonine kinase
- protein binding
- Protein kinase domain
- Tyrosine kinase, catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- Crohn disease
- testicular germ cell tumor
- germ cell neoplasia
regulates
role in cell
- expression in
- quantity
- ploidy
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- centrosome
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CDKL2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sex differentiation
- signal transduction
- regulation of cell cycle
- protein phosphorylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- cytoplasm
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein kinase activity
- cyclin-dependent protein kinase activity
- protein serine/threonine kinase activity