Cdkl2 Gene Summary [Mouse]
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in regulation of cell cycle. Predicted to be located in centrosome and nucleoplasm. Predicted to be active in nucleus. Is expressed in brain; male reproductive gland or organ; metanephros; and parathyroid gland. Orthologous to human CDKL2 (cyclin dependent kinase like 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cdkl2 |
| Official Name | cyclin-dependent kinase-like 2 (CDC2-related kinase) [Source:MGI Symbol;Acc:MGI:1858227] |
| Ensembl ID | ENSMUSG00000029403 |
| Bio databases IDs | |
| Aliases | cyclin-dependent kinase-like 2 (CDC2-related kinase) |
| Synonyms | 5330436L21Rik, cyclin dependent kinase like 2, KKIAMRE, Kkm, P56 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cdkl2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- Protein Kinases, catalytic domain
- Protein tyrosine and serine/threonine kinase
- protein binding
- Protein kinase domain
- Tyrosine kinase, catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- Crohn disease
- testicular germ cell tumor
- germ cell neoplasia
regulates
role in cell
- expression in
- quantity
- ploidy
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- centrosome
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cdkl2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sex differentiation
- signal transduction
- regulation of cell cycle
- protein phosphorylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- cytoplasm
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein kinase activity
- cyclin-dependent protein kinase activity
- protein serine/threonine kinase activity