CDK14
CDK14 Gene Summary
Enables cyclin binding activity and cyclin-dependent protein serine/threonine kinase activity. Involved in G2/M transition of mitotic cell cycle and regulation of canonical Wnt signaling pathway. Located in cytosol; nucleoplasm; and plasma membrane. Part of cytoplasmic cyclin-dependent protein kinase holoenzyme complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | CDK14 |
| Official Name | cyclin dependent kinase 14 [Source:HGNC Symbol;Acc:HGNC:8883] |
| Ensembl ID | ENSG00000058091 |
| Bio databases IDs | |
| Aliases | cyclin dependent kinase 14 |
| Synonyms | cyclin-dependent kinase 14,mKIAA0834,PFTAIRE1,PFTK1 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- cyclin-dependent protein kinase
- kinase domain
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- Protein Kinases, catalytic domain
- protein binding
- Protein kinase domain
- Tyrosine kinase, catalytic domain
- cyclin binding
Pathways
Biological processes and signaling networks where the CDK14 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- CDKN1A
- YWHAQ
- TOP1
- YWHAB
- HSP90AB1
- RPSA2
- CDKL2
- YWHAH
- FGR
- CCND3
disease
- metastasis
- neoplasia
- liver cancer
- epithelial cancer
- acute myeloid leukemia
- glomerulonephritis
- idiopathic scoliosis
- hepatocellular carcinoma
- HER2 negative hormone receptor negative breast cancer
regulated by
- forskolin
- LH
- METTL1
- arsenite
- doxorubicin
- AR
- poly rI:rC-RNA
- TRH
- CDKN1A
- CCND3
regulates
- ACTB
- SNCA
- 2-deoxyglucose
- CTNNB1
- TAGLN2
- actin
- LRP6
- RB
role in cell
- tyrosine phosphorylation in
- phosphorylation in
- proliferation
- outgrowth
- growth
- serine phosphorylation in
- binding in
- invasiveness
- cell cycle progression
- motility
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Plasma Membrane
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the CDK14 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- cell division
- G2/M transition of mitotic cell cycle
- regulation of canonical Wnt receptor signaling pathway
- Wnt receptor signaling pathway
- regulation of cell cycle
- protein phosphorylation
CELLULAR COMPONENT
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytoplasmic cyclin-dependent protein kinase holoenzyme complex
- cyclin-dependent protein kinase holoenzyme complex
- cytosol
- plasma membrane
- nucleoplasm
MOLECULAR FUNCTION
What the gene product does at the molecular level
- ATP binding
- protein binding
- cyclin binding
- cyclin-dependent protein kinase activity