ERP27 Gene Summary [Human]
This gene encodes a noncatalytic member of the protein disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins. The canonical protein has an N-terminal signal sequence, two thioredoxin (TRX)-like domains and a C-terminal ER-retention sequence. Alternative splicing results in multiple transcript variants encoding distinct isoforms; some of which lack domains present in the canonical protein. [provided by RefSeq, Dec 2016]
Details
| Type | Protein Coding |
| Official Symbol | ERP27 |
| Official Name | endoplasmic reticulum protein 27 [Source:HGNC Symbol;Acc:HGNC:26495] |
| Ensembl ID | ENSG00000139055 |
| Bio databases IDs | |
| Aliases | endoplasmic reticulum protein 27, protein disulfide isomerase family A, member 8 |
| Synonyms | 1810033M07Rik, 1810047B09Rik, C12orf46, endoplasmic reticulum protein 27, PDIA8, RGD1565381 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ERP27 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- thioredoxin-like domain
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ERP27 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein folding
- response to unfolded protein
- response to endoplasmic reticulum stress
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein disulfide isomerase activity