SERPINB2
SERPINB2 Gene Summary
Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity. Predicted to be located in extracellular region and plasma membrane. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | SERPINB2 |
| Official Name | serpin family B member 2 [Source:HGNC Symbol;Acc:HGNC:8584] |
| Ensembl ID | ENSG00000197632 |
| Bio databases IDs | |
| Aliases | serpin family B member 2, plasminogen-activator inhibitor |
| Synonyms | HsT1201,Monocyte Arg-serpin,ovalbumin,PAI,PAI-2,PAI2A,PLANH2,serine (or cysteine) peptidase inhibitor, clade B, member 2,serpin family B member 2 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SERine Proteinase INhibitors (serpin) family
- serine protease inhibitor activity
- interhelical region
- Serpin (serine protease inhibitor)
- reactive serpin loop
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- OR2A4
- FOSL1
- ERP27
- CALML3
- CFAP298
- CDC42
- ALB
- PPP2R2B
- CUL3
- GOLGA2
disease
- metastasis
- acute myeloid leukemia
- advanced cancer
- cancer
- non-insulin-dependent diabetes mellitus
- psoriasis
- epithelial neoplasia
- papillomatosis
- benign neoplasia
- septic shock
regulated by
- IgE
- GAST
- IL3
- OVALBUMIN
- Ca2+
- TGM2
- IL1B
- IL33
- cycloheximide
- piceatannol
regulates
- IL1B
- PLAT
- p38 MAPK
- ERK
- BAX
- TP53
- PLAU
- BCL2
- JNK
- CASP8
role in cell
- proliferation
- phosphorylation in
- migration
- expression in
- adhesion
- cell death
- differentiation
- degradation in
- binding in
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- nuclear fraction
- cornified envelope
- Cytoplasm
- intracellular space
- Nucleus
- Plasma Membrane
- granules
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the SERPINB2 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- negative regulation of apoptotic process
- negative regulation of endopeptidase activity
- fibrinolysis
CELLULAR COMPONENT
Where in the cell the gene product is active
- cornified envelope
- extracellular space
- cytoplasm
- extracellular region
- plasma membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- serine-type endopeptidase inhibitor activity