AMDHD1 Gene Summary [Human]
Predicted to enable imidazolonepropionase activity. Predicted to be involved in histidine catabolic process. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | AMDHD1 |
| Official Name | amidohydrolase domain containing 1 [Source:HGNC Symbol;Acc:HGNC:28577] |
| Ensembl ID | ENSG00000139344 |
| Bio databases IDs | |
| Aliases | amidohydrolase domain containing 1 |
| Synonyms | 1300019J08Rik, amidohydrolase domain containing 1, HMFT1272, RGD1308879 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human AMDHD1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- imidazolonepropionase
- cyclic amide carbon-nitrogen bond hydrolase
- Amidohydrolase family
- enzyme
- protein binding
- metallo-dependent_hydrolases
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human AMDHD1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- histidine catabolic process
- histidine catabolic process to glutamate and formate
- histidine catabolic process to glutamate and formamide
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
- metal ion binding
- imidazolonepropionase activity