SLC20A1 Gene Summary [Human]
The protein encoded by this gene is a sodium-phosphate symporter that absorbs phosphate from interstitial fluid for use in cellular functions such as metabolism, signal transduction, and nucleic acid and lipid synthesis. The encoded protein is also a retroviral receptor, causing human cells to be susceptible to infection by gibbon ape leukemia virus, simian sarcoma-associated virus, feline leukemia virus subgroup B, and 10A1 murine leukemia virus.[provided by RefSeq, Mar 2011]
Details
| Type | Protein Coding |
| Official Symbol | SLC20A1 |
| Official Name | solute carrier family 20 member 1 [Source:HGNC Symbol;Acc:HGNC:10946] |
| Ensembl ID | ENSG00000144136 |
| Bio databases IDs | |
| Aliases | solute carrier family 20 member 1, gibbon ape leukemia virus receptor 1 |
| Synonyms | GLVR1, leukaemia Virus Receptor, NaPi3, PIT1, Rpho1, solute carrier family 20 member 1, SOLUTE CARRIER family 20, member 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SLC20A1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- high affinity inorganic phosphate:sodium symporter
- signaling receptor activity
- sodium:phosphate symporter
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- organismal death
- aortic valve calcification
- anemia
- hypoplasia
- growth failure
- infection
role in cell
- expression in
- number
- phosphorylation in
- apoptosis
- proliferation
- binding
- cell cycle progression
- mitosis
- mineralization
- cytokinesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SLC20A1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell proliferation
- ion transport
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- sodium ion transmembrane transport
- phosphate-containing compound metabolic process
- phosphate ion transmembrane transport
- biomineral tissue development
Cellular Component
Where in the cell the gene product is active
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- high affinity inorganic phosphate:sodium symporter activity
- inorganic phosphate transmembrane transporter activity
- sodium:phosphate symporter activity
- signaling receptor activity