RITA1 Gene Summary [Human]
Enables tubulin binding activity. Involved in negative regulation of Notch signaling pathway and nuclear export. Located in centrosome; cytoplasm; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | RITA1 |
| Official Name | RBPJ interacting and tubulin associated 1 [Source:HGNC Symbol;Acc:HGNC:25925] |
| Ensembl ID | ENSG00000139405 |
| Bio databases IDs | |
| Aliases | RBPJ interacting and tubulin associated 1, RBP-J interacting and tubulin associated |
| Synonyms | 1110008J03Rik, C12orf52, LOC100503442, RBPJ interacting and tubulin associated 1, RGD1306772, RITA |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RITA1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- tubulin binding
- RBPJ-interacting and tubulin associated protein
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- centrosome
- nucleoplasm
- spindle pole
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RITA1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- Notch signaling pathway
- nuclear export
- neurogenesis
- negative regulation of Notch signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- cytoplasm
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- tubulin binding
- protein binding