TACC3 Gene Summary [Human]
This gene encodes a member of the transforming acidic colied-coil protein family. The encoded protein is a motor spindle protein that may play a role in stabilization of the mitotic spindle. This protein may also play a role in growth a differentiation of certain cancer cells. [provided by RefSeq, Nov 2011]
Details
| Type | Processed Transcript |
| Official Symbol | TACC3 |
| Official Name | transforming acidic coiled-coil containing protein 3 [Source:HGNC Symbol;Acc:HGNC:11524] |
| Ensembl ID | ENSG00000013810 |
| Bio databases IDs | |
| Aliases | transforming acidic coiled-coil containing protein 3 |
| Synonyms | Aint, ERIC-1, MASKIN, Tacc4, transforming acidic coiled-coil containing protein 3, transforming, acidic coiled-coil containing protein 3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TACC3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Yuri gagarin
- Transforming acidic coiled-coil-containing protein (TACC), C-terminal
- transforming acidic coiled-coil domain
- coiled-coil domain
- protein domain specific binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- osteoarthritis
- knee osteoarthritis
- hip osteoarthritis
- neoplasia
- hypoplasia
- growth failure
- hip or knee osteoarthritis
- organismal death
- MYC mutation positive B-cell lymphoma
- lymphomagenesis
role in cell
- phosphorylation in
- cell viability
- expression in
- quantity
- apoptosis
- proliferation
- formation
- activity
- cell cycle progression
- colony formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- microtubule aster fraction
- glutaminergic synapse
- intracellular membrane-bounded organelle
- Cytoplasm
- basal bodies
- centrosome
- Golgi Apparatus
- cytosol
- spindle fibers
- synapse
- mitotic spindle
- perikaryon
- dendrites
- postsynaptic density
- excitatory synapses
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TACC3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell proliferation
- cell division
- mitotic spindle organization
- cerebral cortex development
- microtubule cytoskeleton organization
- regulation of mitotic spindle organization
- mitotic metaphase/anaphase transition
Cellular Component
Where in the cell the gene product is active
- mitotic spindle
- cytoplasm
- intracellular membrane-bounded organelle
- centriolar satellite
- spindle pole
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding