PSMA4 Gene Summary [Human]
This gene encodes a core alpha subunit of the 20S proteosome, which is a highly ordered ring-shaped structure composed of four rings of 28 non-identical subunits. Proteasomes cleave peptides in an ATP- and ubiquitin-dependent manner. [provided by RefSeq, Aug 2016]
Details
| Type | Protein Coding |
| Official Symbol | PSMA4 |
| Official Name | proteasome 20S subunit alpha 4 [Source:HGNC Symbol;Acc:HGNC:9533] |
| Ensembl ID | ENSG00000041357 |
| Bio databases IDs | |
| Aliases | proteasome 20S subunit alpha 4, proteasome subunit α3 |
| Synonyms | 20S PROTEASOME alpha 4 subunit, 20S PROTEASOME α 4 subunit, C9, HC9, HsT17706, Macropain subunit C9, proteasome 20S subunit alpha 4, proteasome 20S subunit α 4, proteasome subunit alpha 4, Proteasome subunit c9, proteasome subunit α 4, Proteosome subunit α 4, PSC9 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PSMA4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ntn_hydrolase
- proteasome endopeptidase complex
- Proteasome subunit A N-terminal signature
- peptidase
- Proteasome subunit A N-terminal signature Add an annotation
- proteasome endopeptidase complex, archaeal, alpha subunit
- protein binding
- Proteasome subunit
Pathways
Biological processes and signaling networks where the PSMA4 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- cytoplasmic mRNA processing body
- Nucleus
- cytosol
- nucleoplasm
- clastosomes
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PSMA4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytoplasm
- proteasome core complex
- intracellular membrane-bounded organelle
- proteasome core complex, alpha-subunit complex
- cytoplasmic mRNA processing body
- cytosol
- proteasome complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding