HOOK2 Gene Summary [Human]
Hook proteins are cytosolic coiled-coil proteins that contain conserved N-terminal domains, which attach to microtubules, and more divergent C-terminal domains, which mediate binding to organelles. The Drosophila Hook protein is a component of the endocytic compartment.[supplied by OMIM, Apr 2004]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | HOOK2 |
| Official Name | hook microtubule tethering protein 2 [Source:HGNC Symbol;Acc:HGNC:19885] |
| Ensembl ID | ENSG00000095066 |
| Bio databases IDs | |
| Aliases | hook microtubule tethering protein 2 |
| Synonyms | A630054I03Rik, h-hook2, HK2, hook microtubule-tethering protein 2, mHK2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HOOK2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Crescentin protein
- Hook domain-containing proteins superfamily
- HOOK domain
- protein binding
- Intermediate filament protein
- Calcium binding and coiled-coil domain (CALCOCO1) like
- identical protein binding
- HOOK protein coiled-coil region
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- mother centriole
- intracellular membrane-bounded organelle
- basal bodies
- centrosome
- Golgi Apparatus
- microtubules
- cytosol
- trans Golgi network
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HOOK2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lysosome organization
- cytoskeleton-dependent intracellular transport
- endosome organization
- early endosome to late endosome transport
- protein transport
- endosome to lysosome transport
- cytoplasmic microtubule organization
- endocytosis
Cellular Component
Where in the cell the gene product is active
- centrosome
- trans-Golgi network
- cytoplasm
- FHF complex
- intracellular membrane-bounded organelle
- cytosol
- HOPS complex
- microtubule
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- dynein light intermediate chain binding
- microtubule binding