TSSK4 Gene Summary [Human]
This gene encodes a member of the testis-specific serine/threonine kinase family. The encoded protein is thought to be involved in spermatogenesis via stimulation of the CREB/CRE responsive pathway through phosphorylation of the cAMP responsive element binding protein transcription factor. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Details
| Type | Protein Coding |
| Official Symbol | TSSK4 |
| Official Name | testis specific serine kinase 4 [Source:HGNC Symbol;Acc:HGNC:19825] |
| Ensembl ID | ENSG00000139908 |
| Bio databases IDs | |
| Aliases | testis specific serine kinase 4, chromosome 14 open reading frame 20 |
| Synonyms | 1700020B19Rik, 4933424F08Rik, C14orf20, RGD1560814, STK22E, testis-specific serine kinase 4, TSK-4, TSSK5 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TSSK4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- protein serine/threonine kinase
- binding protein
- Protein Kinases, catalytic domain
- ATP binding
- protein homodimerization
- protein binding
- Protein kinase domain
- magnesium ion binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- motile cilia
- sperm tail
- acrosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TSSK4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sperm motility
- spermatid development
- fertilization
- positive regulation of CREB transcription factor activity
- protein phosphorylation
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- acrosomal vesicle
- sperm flagellum
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- ATP binding
- protein homodimerization activity
- protein binding
- protein serine/threonine kinase activity