WDR3 Gene Summary [Human]

This gene encodes a nuclear protein containing 10 WD repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, which usually include a trp-asp at the C-terminal end. Proteins belonging to the WD repeat family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. [provided by RefSeq, Jul 2008]

Details

Type
Processed Transcript
Official Symbol
WDR3
Official Name
WD repeat domain 3 [Source:HGNC Symbol;Acc:HGNC:12755]
Ensembl ID
ENSG00000065183
Bio databases IDs NCBI: 10885 Ensembl: ENSG00000065183
Aliases WD repeat domain 3
Synonyms D030020G18Rik, DIP2, UTP12, WD repeat domain 3
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human WDR3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • WD40 repeats
  • WD domain, G-beta repeat
  • WD40
  • Dip2/Utp12 Family

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulated by
  • VPC-220010
  • aphidicolin
  • CST5
  • NR3C1
  • Influenza A virus (A/Japan/305/57(H2N2))
  • bisphenol A
  • tretinoin
  • ACHE
  • GABA
  • STAT5A/B
role in cell
  • processing in

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • pre-ribosome
  • Nucleus
  • nucleoplasm
  • nucleoli
  • nuclear envelope

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human WDR3 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • maturation of SSU-rRNA
  • ribosomal small subunit biogenesis

Cellular Component

Where in the cell the gene product is active
  • small-subunit processome
  • nuclear membrane
  • Pwp2p-containing subcomplex of 90S preribosome
  • nucleolus
  • nucleoplasm

Molecular Function

What the gene product does at the molecular level
  • snoRNA binding
  • RNA binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.