Tssk4 Gene Summary [Mouse]
Enables magnesium ion binding activity; protein homodimerization activity; and protein serine/threonine kinase activity. Involved in several processes, including flagellated sperm motility; positive regulation of CREB transcription factor activity; and protein phosphorylation. Located in sperm flagellum. Orthologous to human TSSK4 (testis specific serine kinase 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tssk4 |
| Official Name | testis-specific serine kinase 4 [Source:MGI Symbol;Acc:MGI:1918349] |
| Ensembl ID | ENSMUSG00000007591 |
| Bio databases IDs | |
| Aliases | testis-specific serine kinase 4 |
| Synonyms | 1700020B19Rik, 4933424F08Rik, C14orf20, RGD1560814, STK22E, testis-specific serine kinase 4, TSK-4, TSSK5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tssk4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- protein serine/threonine kinase
- binding protein
- Protein Kinases, catalytic domain
- ATP binding
- protein homodimerization
- protein binding
- Protein kinase domain
- magnesium ion binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- motile cilia
- sperm tail
- acrosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tssk4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sperm motility
- spermatid development
- fertilization
- positive regulation of CREB transcription factor activity
- protein phosphorylation
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- acrosomal vesicle
- sperm flagellum
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- ATP binding
- protein homodimerization activity
- protein binding
- protein serine/threonine kinase activity