ACACB
ACACB Gene Summary
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. ACC-beta is thought to control fatty acid oxidation by means of the ability of malonyl-CoA to inhibit carnitine-palmitoyl-CoA transferase I, the rate-limiting step in fatty acid uptake and oxidation by mitochondria. ACC-beta may be involved in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. [provided by RefSeq, Oct 2022]
Details
| Type | Protein Coding |
| Official Symbol | ACACB |
| Official Name | acetyl-CoA carboxylase beta [Source:HGNC Symbol;Acc:HGNC:85] |
| Ensembl ID | ENSG00000076555 |
| Bio databases IDs | |
| Aliases | acetyl-CoA carboxylase beta, acetyl-CoA carboxylase 2 |
| Synonyms | ACACbeta,ACC2,ACCB,ACC-beta,ACC-β,acetyl-CoA carboxylase beta,acetyl-CoA carboxylase β,acetyl-Coenzyme A carboxylase beta,acetyl-Coenzyme A carboxylase β,AW743042,C87246,HACC275,LOC283445 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- biotin binding
- ATP-grasp domain
- Biotin carboxylase C-terminal domain
- enzyme
- protein binding
- identical protein binding
- Acetyl-CoA carboxylase, central region
- Biotinyl_lipoyl_domains
- Carbamoyl-phosphate synthase L chain, ATP binding domain
- Biotin carboxylase, N-terminal domain
- biotin carboxylase
- Biotin-requiring enzyme
- Carboxyl transferase domain
- acetyl-CoA carboxylase
- PRK12999
Pathways
Biological processes and signaling networks where the ACACB gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- YES1
- HMGA1
- GSK3A
- HUWE1
- PAK6
- HSPB1
- PRKAA1
- EGFR
- GRAMD1A
- TCF3
disease
- epithelial cancer
- liver cancer
- obesity
- pervasive developmental disorder
- cervical carcinoma
- epithelial uterine cancer
- cervical cancer
- insulin resistance
- ductal breast carcinoma
- ductal breast cancer
regulated by
- methotrexate
- cisplatin
- SREBF1
- DNM1L
- sirolimus
- metribolone
- isoproterenol
- tretinoin
- NR1H
- AICAR
regulates
- AKT
- PPARG
- SLC2A4
- cholesterol
- D-glucose
- lipid
- LEP
- palmitic acid
- CPT1
- fat
role in cell
- growth in
- lipolysis in
- generation in
- accumulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Mitochondria
- cytosol
- mitochondrial outer membrane
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the ACACB gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- malonyl-CoA biosynthetic process
- positive regulation of heart growth
- pentose-phosphate shunt
- acetyl-CoA metabolic process
- lactic acid secretion
- response to nutrient
- glucose import
- response to organic cyclic compound
- response to xenobiotic stimulus
- fatty acid biosynthetic process
- negative regulation of gene expression
- tricarboxylic acid metabolic process
- protein homotetramerization
- regulation of glucose metabolic process
- negative regulation of fatty acid beta-oxidation
- fatty acid oxidation
- energy homeostasis
- positive regulation of lipid storage
CELLULAR COMPONENT
Where in the cell the gene product is active
- nucleus
- mitochondrial fatty acid beta-oxidation multienzyme complex
- mitochondrion
- cytosol
- mitochondrial outer membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- ATP binding
- identical protein binding
- protein binding
- metal ion binding
- acetyl-CoA carboxylase activity
- biotin binding