NKD1 Gene Summary [Human]
In the mouse, Nkd is a Dishevelled (see DVL1; MIM 601365)-binding protein that functions as a negative regulator of the Wnt (see WNT1; MIM 164820)-beta-catenin (see MIM 116806)-Tcf (see MIM 602272) signaling pathway.[supplied by OMIM, Jun 2003]
Details
| Type | Processed Transcript |
| Official Symbol | NKD1 |
| Official Name | NKD inhibitor of WNT signaling pathway 1 [Source:HGNC Symbol;Acc:HGNC:17045] |
| Ensembl ID | ENSG00000140807 |
| Bio databases IDs | |
| Aliases | NKD inhibitor of WNT signaling pathway 1 |
| Synonyms | 2810434J10Rik, 9030215G15Rik, LOC283859, Naked1, naked cuticle 1, Nkd, NKD inhibitor of WNT signaling pathway 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NKD1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- PDZ-domain binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hyperplasia
- liver cancer
- familial adenomatous polyposis
- enteritis
- oligozoospermia
- inflammatory bowel disease
- brain cancer
- medulloblastoma WNT-subtype
role in cell
- expression in
- proliferation
- generation in
- migration
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NKD1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell motility involved in somitogenic axis elongation
- positive regulation of non-canonical Wnt receptor signaling pathway
- positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway
- positive regulation of protein catabolic process
- positive regulation of MAPK cascade
- convergent extension
- somatic muscle development
- negative regulation of canonical Wnt receptor signaling pathway
- axis elongation
- eye photoreceptor cell differentiation
- Wnt receptor signaling pathway
- negative regulation of Wnt receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- protein phosphatase type 2A complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding
- PDZ domain binding