Nkd1 Gene Summary [Mouse]
Enables PDZ domain binding activity. Involved in several processes, including convergent extension; positive regulation of MAPK cascade; and regulation of Wnt signaling pathway. Predicted to be located in plasma membrane. Predicted to be part of protein phosphatase type 2A complex. Predicted to be active in cytoplasm. Is expressed in several structures, including brain; genitourinary system; gut; retina; and unsegmented mesenchyme. Orthologous to human NKD1 (NKD inhibitor of WNT signaling pathway 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nkd1 |
| Official Name | naked cuticle 1 [Source:MGI Symbol;Acc:MGI:2135954] |
| Ensembl ID | ENSMUSG00000031661 |
| Bio databases IDs | |
| Aliases | naked cuticle 1 |
| Synonyms | 2810434J10Rik, 9030215G15Rik, LOC283859, Naked1, naked cuticle 1, Nkd, NKD inhibitor of WNT signaling pathway 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nkd1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- PDZ-domain binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hyperplasia
- liver cancer
- familial adenomatous polyposis
- enteritis
- oligozoospermia
- inflammatory bowel disease
- brain cancer
- medulloblastoma WNT-subtype
role in cell
- expression in
- proliferation
- generation in
- migration
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nkd1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell motility involved in somitogenic axis elongation
- positive regulation of non-canonical Wnt receptor signaling pathway
- positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway
- positive regulation of protein catabolic process
- positive regulation of MAPK cascade
- convergent extension
- somatic muscle development
- negative regulation of canonical Wnt receptor signaling pathway
- axis elongation
- eye photoreceptor cell differentiation
- Wnt receptor signaling pathway
- negative regulation of Wnt receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- protein phosphatase type 2A complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding
- PDZ domain binding