WRAP53 Gene Summary [Human]
This gene encodes an essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex required for telomere synthesis. This protein is enriched in Cajal bodies, nuclear sites of RNP processing that are important for telomerase function. It interacts with dyskerin, TERT and TERC, other components of active telomerase, and with small Cajal body RNAs (scaRNAs), which are involved in modifying splicing RNAs. This mRNA also functions as a p53 antisense transcript, that regulates endogenous p53 mRNA levels and further induction of p53 protein by targeting the 5' untranslated region of p53 mRNA. Alternatively spliced transcript variants which differ only in the 5' UTR have been found for this gene. [provided by RefSeq, Mar 2011]
Details
| Type | Protein Coding |
| Official Symbol | WRAP53 |
| Official Name | WD repeat containing antisense to TP53 [Source:HGNC Symbol;Acc:HGNC:25522] |
| Ensembl ID | ENSG00000141499 |
| Bio databases IDs | |
| Aliases | WD repeat containing antisense to TP53, telomerase cajal body protein 1, WD-encoding RNA antisense to p53 |
| Synonyms | DKCB3, TCAB1, WDR79, WD repeat containing antisense to TP53, WD repeat containing, antisense to TP53, WD repeat containing, antisense to Trp53 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human WRAP53 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- histone binding
- binding protein
- WD40 repeats
- WD domain, G-beta repeat
- WD40
- protein binding
- chaperone binding
- identical protein binding
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- autosomal recessive dyskeratosis congenita type 3
- dyskeratosis congenita
- plexiform neurofibroma
- gastric epithelial cancer
- hereditary cancer-predisposing syndrome
- gastric carcinoma
role in cell
- expression in
- apoptosis
- synthesis in
- quantity
- proliferation
- migration
- Gap 0-Gap 1 phase
- invasion by
- colony formation
- frequency
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
- nuclear bodies
- Cajal bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human WRAP53 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of DNA repair
- DNA repair
- positive regulation of telomerase activity
- telomere maintenance via telomerase
- positive regulation of double-strand break repair
- positive regulation of double-strand break repair via nonhomologous end joining
- Cajal body organization
- telomere formation via telomerase
- RNA folding
Cellular Component
Where in the cell the gene product is active
- chromosome, telomeric region
- nuclear body
- site of double-strand break
- Cajal body
- cytosol
- telomerase holoenzyme complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- RNA binding
- ubiquitin protein ligase binding
- telomeric RNA binding
- histone binding
- chaperone binding