POLR3F Gene Summary [Human]
The protein encoded by this gene is one of more than a dozen subunits forming eukaryotic RNA polymerase III (RNA Pol III), which transcribes 5S ribosomal RNA and tRNA genes. This protein has been shown to bind both TFIIIB90 and TBP, two subunits of RNA polymerase III transcription initiation factor IIIB (TFIIIB). Unlike most of the other RNA Pol III subunits, the encoded protein is unique to this polymerase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Details
| Type | Protein Coding |
| Official Symbol | POLR3F |
| Official Name | RNA polymerase III subunit F [Source:HGNC Symbol;Acc:HGNC:15763] |
| Ensembl ID | ENSG00000132664 |
| Bio databases IDs | |
| Aliases | RNA polymerase III subunit F, RNA polymerase III C39 subunit |
| Synonyms | 2810411G20Rik, 3010019O03RIK, 3110032A07Rik, C34, IMD101, polymerase (RNA) III (DNA directed) polypeptide F, RNA polymerase III subunit F, RPC39, RPC6 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human POLR3F often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- double-stranded DNA binding
- RNA polymerase Rpc34 subunit
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human POLR3F gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of innate immune response
- transcription from RNA polymerase III promoter
- innate immune response
- positive regulation of interferon-beta production
- defense response to virus
- regulation of transcription from RNA polymerase III promoter
Cellular Component
Where in the cell the gene product is active
- cytosol
- DNA-directed RNA polymerase III complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA-directed RNA polymerase activity
- protein binding
- double-stranded DNA binding
- 4 iron, 4 sulfur cluster binding