Wrap53 Gene Summary [Mouse]
Enables RNA folding chaperone. Predicted to be involved in several processes, including RNA localization to Cajal body; positive regulation of double-strand break repair; and telomere organization. Predicted to be located in cytosol; nuclear body; and site of double-strand break. Predicted to be part of telomerase holoenzyme complex. Predicted to be active in Cajal body. Is expressed in palatal shelf. Human ortholog(s) of this gene implicated in autosomal recessive dyskeratosis congenita 3; colorectal cancer; head and neck squamous cell carcinoma; lung non-small cell carcinoma; and ovarian cancer. Orthologous to human WRAP53 (WD repeat containing antisense to TP53). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Wrap53 |
| Official Name | WD repeat containing, antisense to Trp53 [Source:MGI Symbol;Acc:MGI:2384933] |
| Ensembl ID | ENSMUSG00000041346 |
| Bio databases IDs | |
| Aliases | WD repeat containing, antisense to Trp53 |
| Synonyms | DKCB3, TCAB1, WDR79, WD repeat containing antisense to TP53, WD repeat containing, antisense to TP53, WD repeat containing, antisense to Trp53 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Wrap53 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- histone binding
- binding protein
- WD40 repeats
- WD domain, G-beta repeat
- WD40
- protein binding
- chaperone binding
- identical protein binding
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- autosomal recessive dyskeratosis congenita type 3
- dyskeratosis congenita
- plexiform neurofibroma
- gastric epithelial cancer
- hereditary cancer-predisposing syndrome
- gastric carcinoma
regulates
- TP53
- TERC
role in cell
- expression in
- apoptosis
- synthesis in
- quantity
- proliferation
- migration
- Gap 0-Gap 1 phase
- invasion by
- colony formation
- frequency
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
- nuclear bodies
- Cajal bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Wrap53 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of DNA repair
- DNA repair
- positive regulation of telomerase activity
- telomere maintenance via telomerase
- positive regulation of double-strand break repair
- positive regulation of double-strand break repair via nonhomologous end joining
- Cajal body organization
- telomere formation via telomerase
- RNA folding
Cellular Component
Where in the cell the gene product is active
- chromosome, telomeric region
- nuclear body
- site of double-strand break
- Cajal body
- cytosol
- telomerase holoenzyme complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- RNA binding
- ubiquitin protein ligase binding
- telomeric RNA binding
- histone binding
- chaperone binding