IL19
IL19 Gene Summary
The protein encoded by this gene is a cytokine that belongs to the IL10 cytokine subfamily. This cytokine is found to be preferentially expressed in monocytes. It can bind the IL20 receptor complex and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). A similar cytokine in mouse is reported to up-regulate the expression of IL6 and TNF-alpha and induce apoptosis, which suggests a role of this cytokine in inflammatory responses. Alternatively spliced transcript variants encoding the distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Details
| Type | Processed Transcript |
| Official Symbol | IL19 |
| Official Name | interleukin 19 [Source:HGNC Symbol;Acc:HGNC:5990] |
| Ensembl ID | ENSG00000142224 |
| Bio databases IDs | |
| Aliases | interleukin 19, melanoma differentiation associated protein-like protein |
| Synonyms | IL-10C,interleukin 19,LOC681872,MDA1,NG.1,ZMDA1 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- cytokine
- Interleukin 10
Pathways
Biological processes and signaling networks where the IL19 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- MECP2
- IL20RA
- IL20RB
- ZMPSTE24
- S100A6
disease
- Parkinson disease
- psoriasis
- inflammatory bowel disease
- Alzheimer disease
- osteoporosis
- pruritus
- mouth mucosal ulcer
- neutropenia
- cholangiocarcinoma
- cholangiocarcinoma cancer
regulated by
- beta-estradiol
- IL17A
- IL1B
- imiquimod
- cyclosporin
- TRAF3IP2
- IL22
- NFkB (complex)
- NFE2L2
- HBEGF
regulates
- MMP9
- IFNG
- TNF
- CCL2
- IL6
- reactive oxygen species
- HMOX1
- STAT3
- TNF (family)
- STAT6
role in cell
- production in
- expression in
- quantity
- apoptosis
- growth
- proliferation
- formation
- phosphorylation in
- migration
- gemcitabine resistance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the IL19 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- reactive oxygen species metabolic process
- immune response
- negative regulation of low-density lipoprotein particle clearance
- signal transduction
- apoptotic process
- negative regulation of extrinsic apoptotic signaling pathway
- positive regulation of intrinsic apoptotic signaling pathway
CELLULAR COMPONENT
Where in the cell the gene product is active
- extracellular space
- extracellular region
MOLECULAR FUNCTION
What the gene product does at the molecular level
- cytokine activity