Il19 Gene Summary [Mouse]
Predicted to enable cytokine activity. Involved in negative regulation of low-density lipoprotein particle clearance. Acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway; positive regulation of intrinsic apoptotic signaling pathway; and reactive oxygen species metabolic process. Predicted to be active in extracellular space. Orthologous to human IL19 (interleukin 19). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Il19 |
| Official Name | interleukin 19 [Source:MGI Symbol;Acc:MGI:1890472] |
| Ensembl ID | ENSMUSG00000016524 |
| Bio databases IDs | |
| Aliases | interleukin 19 |
| Synonyms | IL-10C, interleukin 19, LOC681872, MDA1, NG.1, ZMDA1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Il19 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- cytokine
- Interleukin 10
Pathways
Biological processes and signaling networks where the Il19 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Parkinson disease
- psoriasis
- inflammatory bowel disease
- Alzheimer disease
- osteoporosis
- pruritus
- mouth mucosal ulcer
- neutropenia
- cholangiocarcinoma
- cholangiocarcinoma cancer
role in cell
- production in
- expression in
- quantity
- apoptosis
- growth
- proliferation
- formation
- phosphorylation in
- migration
- gemcitabine resistance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Il19 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- reactive oxygen species metabolic process
- immune response
- negative regulation of low-density lipoprotein particle clearance
- signal transduction
- apoptotic process
- negative regulation of extrinsic apoptotic signaling pathway
- positive regulation of intrinsic apoptotic signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- cytokine activity