IL20RB Gene Summary [Human]
IL20RB and IL20RA (MIM 605620) form a heterodimeric receptor for interleukin-20 (IL20; MIM 605619) (Blumberg et al., 2001 [PubMed 11163236]).[supplied by OMIM, Feb 2009]
Details
| Type | Processed Transcript |
| Official Symbol | IL20RB |
| Official Name | interleukin 20 receptor subunit beta [Source:HGNC Symbol;Acc:HGNC:6004] |
| Ensembl ID | ENSG00000174564 |
| Bio databases IDs | |
| Aliases | interleukin 20 receptor subunit beta |
| Synonyms | DIRS1, FNDC6, Gm186, IL-20R2, IL-20R-beta, IL-20R-β, interleukin 20 receptor beta, interleukin 20 receptor subunit beta, interleukin 20 receptor subunit β, interleukin 20 receptor β, RGD1566151 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IL20RB often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- FN3
- protein binding
- Interferon-alpha/beta receptor, fibronectin type III
- Tissue factor
- interleukin-20 binding
Pathways
Biological processes and signaling networks where the IL20RB gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- prostate cancer
- prostatic carcinoma
- organismal death
- pancreatic epithelial cancer
- collagen-induced arthritis
- psoriasis
- pancreatic cancer
- delayed hypersensitive reaction
role in cell
- binding in
- expression in
- number
- proliferation
- phosphorylation in
- activation in
- formation
- activation
- gemcitabine resistance
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IL20RB gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- T cell homeostasis
- immune response-inhibiting signal transduction
- negative regulation of interleukin-2 production
- inflammatory response to antigenic stimulus
- homeostasis of number of cells within a tissue
- cytokine-mediated signaling pathway
- negative regulation of T cell proliferation
- T cell proliferation
- positive regulation of interleukin-10 production
- negative regulation of interferon-gamma production
- negative regulation of type IV hypersensitivity
- positive regulation of interleukin-4 production
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- interleukin-20 binding
- cytokine receptor activity