SLC47A1 Gene Summary [Human]
This gene is located within the Smith-Magenis syndrome region on chromosome 17. It encodes a protein of unknown function. [provided by RefSeq, Jul 2008]
Details
| Type | Processed Transcript |
| Official Symbol | SLC47A1 |
| Official Name | solute carrier family 47 member 1 [Source:HGNC Symbol;Acc:HGNC:25588] |
| Ensembl ID | ENSG00000142494 |
| Bio databases IDs | |
| Aliases | solute carrier family 47 member 1, multidrug and toxin extrusion 1 |
| Synonyms | FLJ10847, MATE1, solute carrier family 47 member 1 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SLC47A1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- hydrogen ion transporter
- MatE
- L-amino acid transporter
- protein binding
- basic amino acid transporter
- putative efflux protein, MATE family
- organic cation transporter
- Multidrug and toxic compound extrusion family and similar proteins
- xenobiotic transporter
- antiporter
- thiamin transporter
- transporter
- putrescine transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- dermatomyositis
- chronic kidney disease
- gout
- cerebral aneurysm
regulated by
- D-glucose
- PPARA
- RSL3
- torin1
- methylnitrosourea
- 7,8-dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
- MIR181A
- MIR181B
- iruplinalkib
regulates
- lipid
- chloroquine
- cholesteryl arachidonate
- tetraethylammonium
- 1-methyl-4-phenylpyridinium
- organic cation
- cholesteryl docosahexaenoate
- cisplatin
- cholesterol docosapentaenoate
- putrescine
role in cell
- accumulation in
- production in
- cell death
- ferroptosis
- peroxidation in
- transcellular transport in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- apical membrane
- basolateral membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SLC47A1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- drug transmembrane transport
- organic cation transport
- transmembrane transport
- xenobiotic transport
- putrescine transport
- thiamine transmembrane transport
Cellular Component
Where in the cell the gene product is active
- membrane
- basolateral plasma membrane
- plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- putrescine transmembrane transporter activity
- xenobiotic transporter activity
- thiamine transmembrane transporter activity
- L-amino acid transmembrane transporter activity
- organic cation transmembrane transporter activity
- protein binding
- transmembrane transporter activity
- antiporter activity