PODXL2
PODXL2 Gene Summary
This gene is a member of the CD34 family of cell surface transmembrane proteins, which are characterized by an N-terminal extracellular mucin domain, globular and stalk domains, a single pass transmembrane region, and a charged cytoplasmic tail. The encoded protein is a ligand for vascular selectins. [provided by RefSeq, Oct 2012]
Details
| Type | Protein Coding |
| Official Symbol | PODXL2 |
| Official Name | podocalyxin like 2 [Source:HGNC Symbol;Acc:HGNC:17936] |
| Ensembl ID | ENSG00000114631 |
| Bio databases IDs | |
| Aliases | podocalyxin like 2, endoglycan |
| Synonyms | D130074J02Rik,EG,PODLX2,podocalyxin-like 2,RGD1305815 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CD34/Podocalyxin family
- protein binding
- glycosaminoglycan binding
Pathways
Biological processes and signaling networks where the PODXL2 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- BMPR1A
- APOA1
- TNIP1
- RAET1E
- SNX27
- CRLF2
- CTLA4
- ECPAS
- RAB11A
- BSG
disease
- lung adenocarcinoma formation
- lung adenocarcinoma
regulated by
- MGA
- tetradecanoylphorbol acetate
- STAT5A
- ADAM10
- ACHE
- NEU2
- SNX27
- Retromer
- CBX5
- F3
regulates
role in cell
- branching
- cell tethering or rolling by
- cell rolling
- branching in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Golgi lumen
- cell surface
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the PODXL2 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- leukocyte tethering or rolling
CELLULAR COMPONENT
Where in the cell the gene product is active
- Golgi lumen
- plasma membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein binding
- glycosaminoglycan binding