SIGLEC10 Gene Summary [Human]
SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).[supplied by OMIM, Jul 2002]
Details
| Type | Protein Coding |
| Official Symbol | SIGLEC10 |
| Official Name | sialic acid binding Ig like lectin 10 [Source:HGNC Symbol;Acc:HGNC:15620] |
| Ensembl ID | ENSG00000142512 |
| Bio databases IDs | |
| Aliases | sialic acid binding Ig like lectin 10, sialic acid binding Ig-like lectin 10 Ig-like lectin 7, siglec-like gene 2 |
| Synonyms | A630096C01RIK, PRO940, sialic acid binding Ig-like lectin 10, Siglecg, SLG2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SIGLEC10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- immunoreceptor tyrosine-based inhibition motif
- SH2-domain binding
- immunoglobulin domain
- Immunoglobulin like
- Immunoglobulin I-set domain
- protein binding
- Immunoglobulin V-set domain
- phosphatase binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- cutaneous sarcoidosis
- sarcoma
role in cell
- production in
- phagocytosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- Extracellular Space
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SIGLEC10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- innate immune response
- adaptive immune response
- cell adhesion
Cellular Component
Where in the cell the gene product is active
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphatase binding
- protein binding
- sialic acid binding
- SH2 domain binding
- carbohydrate binding