PSMA5 Gene Summary [Human]
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010]
Details
| Type | Protein Coding |
| Official Symbol | PSMA5 |
| Official Name | proteasome 20S subunit alpha 5 [Source:HGNC Symbol;Acc:HGNC:9534] |
| Ensembl ID | ENSG00000143106 |
| Bio databases IDs | |
| Aliases | proteasome 20S subunit alpha 5 |
| Synonyms | Aa409047, Macropain zeta chain, Macropain ζ chain, proteasome 20S subunit alpha 5, proteasome 20S subunit α 5, proteasome subunit alpha 5, proteasome subunit α 5, PSC5, ZETA, ζ |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PSMA5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ntn_hydrolase
- proteasome endopeptidase complex
- Proteasome subunit A N-terminal signature
- peptidase
- Proteasome subunit A N-terminal signature Add an annotation
- proteasome endopeptidase complex, archaeal, alpha subunit
- protein binding
- Proteasome subunit
Pathways
Biological processes and signaling networks where the PSMA5 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pervasive developmental disorder
- infection by HIV-1
role in cell
- apoptosis
- growth
- cell death
- cell viability
- autophagy
- autophagy in
- JQ1-sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- secretory granule lumen
- ficolin-1-rich granule lumen
- Extracellular Space
- Nucleus
- Plasma Membrane
- Golgi Apparatus
- cytosol
- nucleoplasm
- clastosomes
- recycling endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PSMA5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytoplasm
- proteasome core complex
- proteasome core complex, alpha-subunit complex
- cytosol
- secretory granule lumen
- proteasome complex
- extracellular region
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding