AKIRIN2 Gene Summary [Human]
Enables enzyme binding activity and identical protein binding activity. Predicted to be involved in positive regulation of innate immune response and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within positive regulation of interleukin-6 production and response to lipopolysaccharide. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | AKIRIN2 |
| Official Name | akirin 2 [Source:HGNC Symbol;Acc:HGNC:21407] |
| Ensembl ID | ENSG00000135334 |
| Bio databases IDs | |
| Aliases | akirin 2 |
| Synonyms | 2700059D21Rik, C6orf166, dJ486L4.2, FBI1, MGC90611, RGD1307791 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human AKIRIN2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding activity, bridging
- enzyme binding
- protein binding
- akirin
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
role in cell
- apoptosis
- growth
- activation in
- proliferation
- expression in
- activation
- quantity
- recruitment in
- tumorigenicity
- transcription in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cellular membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human AKIRIN2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- embryo development ending in birth or egg hatching
- positive regulation of cell proliferation
- adaptive immune response
- cerebral cortex development
- positive regulation of transcription from RNA polymerase II promoter
- defense response to bacterium
- negative regulation of transcription from RNA polymerase II promoter
- regulation of muscle cell differentiation
- negative regulation of gene expression
- positive regulation of adaptive immune response
- positive regulation of B cell activation
- positive regulation of innate immune response
- nucleus-associated proteasomal ubiquitin-dependent protein catabolic process
- protein import into nucleus
- innate immune response
- response to lipopolysaccharide
- proteasome localization
- positive regulation of interleukin-6 production
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- transcriptional repressor complex
- membrane
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- transcription cofactor activity
- protein binding
- protein binding, bridging
- enzyme binding