PSMA1 Gene Summary [Human]
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009]
Details
| Type | Processed Transcript |
| Official Symbol | PSMA1 |
| Official Name | proteasome 20S subunit alpha 1 [Source:HGNC Symbol;Acc:HGNC:9530] |
| Ensembl ID | ENSG00000129084 |
| Bio databases IDs | |
| Aliases | proteasome 20S subunit alpha 1, proteasome subunit α6 |
| Synonyms | 20S PROTEASOME alpha 1 subunit, 20S PROTEASOME α 1 subunit, alpha-type, C2, HC2, HEL-S-275, Macropain subunit C2, NU, PROS30, proteasome 20S subunit alpha 1, proteasome 20S subunit α 1, PROTEASOME COMPONENT C2, Proteasome nu chain, proteasome subunit alpha 1, proteasome subunit α 1, α-type |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PSMA1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ntn_hydrolase
- proteasome endopeptidase complex
- Proteasome subunit A N-terminal signature
- peptidase
- Proteasome subunit A N-terminal signature Add an annotation
- protein binding
- Proteasome subunit
- lipopolysaccharide binding
Pathways
Biological processes and signaling networks where the PSMA1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- non-insulin-dependent diabetes mellitus
- gastric cancer
- endometriosis
- organismal death
- neonatal late-onset sepsis
- infection by HIV-1
role in cell
- cell viability
- replication in
- dipeptide repeat protein sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- centrosome
- cytosol
- nucleoplasm
- clastosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PSMA1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of inflammatory response to antigenic stimulus
- proteasomal ubiquitin-dependent protein catabolic process
- immune system process
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- extracellular vesicular exosome
- cytoplasm
- proteasome core complex
- proteasome core complex, alpha-subunit complex
- cytosol
- proteasome complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- lipopolysaccharide binding