PFDN2 Gene Summary [Human]
This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. [provided by RefSeq, Jul 2008]
Details
| Type | Processed Transcript |
| Official Symbol | PFDN2 |
| Official Name | prefoldin subunit 2 [Source:HGNC Symbol;Acc:HGNC:8867] |
| Ensembl ID | ENSG00000143256 |
| Bio databases IDs | |
| Aliases | prefoldin subunit 2 |
| Synonyms | ESTM27, LOC678975, PFD2, prefoldin 2, prefoldin subunit 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PFDN2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Prefoldin subunit
- prefoldin
- protein binding
- beta-amyloid binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Mitochondria
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PFDN2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cytoskeleton organization
- chaperone-mediated protein folding
- protein stabilization
- protein folding
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- prefoldin complex
- mitochondrion
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding involved in protein folding
- protein binding
- unfolded protein binding
- beta-amyloid binding