UFL1 Gene Summary [Human]
Enables UFM1 ligase activity and protein kinase binding activity. Involved in several processes, including cellular protein modification process; regulation of signal transduction; and reticulophagy. Acts upstream of or within several processes, including positive regulation of cell population proliferation; regulation of proteasomal ubiquitin-dependent protein catabolic process; and response to endoplasmic reticulum stress. Located in endoplasmic reticulum membrane; nucleus; and site of double-strand break. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Processed Transcript |
| Official Symbol | UFL1 |
| Official Name | UFM1 specific ligase 1 [Source:HGNC Symbol;Acc:HGNC:23039] |
| Ensembl ID | ENSG00000014123 |
| Bio databases IDs | |
| Aliases | UFM1 specific ligase 1, novel LZAP-binding protein, Regulator of CDK5RAP3 and DDRGK1 |
| Synonyms | 1810074P20Rik, KIAA0776, Maxer, mKIAA0776, NLBP, RCAD, RGD1309308, UFM1 specific ligase 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human UFL1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin-like protein transferase activity
- protein kinase binding
- E3 UFM1-protein ligase 1
- ubiquitin-like-protein ligase
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- rheumatoid arthritis
- liver cancer
- renal cell carcinoma
- renal cell cancer
- early onset hypertension
role in cell
- phosphorylation in
- apoptosis
- expression in
- proliferation
- differentiation
- invasion by
- activation
- activation in
- colony formation
- disassembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- mitochondrial outer membrane
- neurites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human UFL1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- negative regulation of NF-kappaB transcription factor activity
- regulation of protein localization
- positive regulation of cell proliferation
- positive regulation of glial cell proliferation
- ribosome disassembly
- regulation of I-kappaB kinase/NF-kappaB cascade
- hemopoietic stem cell differentiation
- response to DNA damage stimulus
- negative regulation of T cell mediated immune response to tumor cell
- DNA damage checkpoint
- positive regulation of autophagy
- erythrocyte differentiation
- rescue of stalled ribosome
- negative regulation of apoptotic process
- osteoblast differentiation
- regulation of inflammatory response
- regulation of intracellular estrogen receptor signaling pathway
- negative regulation of T cell activation
- negative regulation of protein ubiquitination
- protein ufmylation
- response to endoplasmic reticulum stress
- regulation of proteasomal ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nucleus
- site of double-strand break
- cytoplasm
- membrane
- cytosol
- macromolecular complex
- endoplasmic reticulum
- mitochondrial outer membrane
- neuron projection
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- UFM1 conjugating enzyme activity