VBP1 Gene Summary [Human]
The protein encoded by this gene interacts with the Von Hippel-Lindau protein to form an intracellular complex. The encoded protein functions as a chaperone protein, and may play a role in the transport of the Von Hippel-Lindau protein from the perinuclear granules to the nucleus or cytoplasm. Alternative splicing and the use of alternate transcription start sites results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Jan 2015]
Details
| Type | Protein Coding |
| Official Symbol | VBP1 |
| Official Name | VHL binding protein 1 [Source:HGNC Symbol;Acc:HGNC:12662] |
| Ensembl ID | ENSG00000155959 |
| Bio databases IDs | |
| Aliases | VHL binding protein 1, prefoldin 3 |
| Synonyms | HIBBJ46, IMIDOPEPTIDASE, PFD3, PFDN3, VHL binding protein 1, von Hippel-Lindau binding protein 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human VBP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Prefoldin subunit
- prefoldin
- protein binding
- beta-amyloid binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
role in cell
- expression in
- growth
- cell viability
- degradation in
- K48 polyubiquitination in
- K63 polyubiquitination in
- polyubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- perinuclear region
- Nucleus
- cytoplasmic aggregates
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human VBP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tubulin complex assembly
- chaperone-mediated protein folding
- protein folding
- microtubule-based process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- prefoldin complex
- intracellular membrane-bounded organelle
- cytosol
Molecular Function
What the gene product does at the molecular level
- tubulin binding
- protein binding
- unfolded protein binding
- beta-amyloid binding