PIGM Gene Summary [Human]
This gene encodes a transmembrane protein that is located in the endoplasmic reticulum and is involved in GPI-anchor biosynthesis. The glycosylphosphatidylinositol (GPI)-anchor is a glycolipid which contains three mannose molecules in its core backbone. The GPI-anchor is found on many blood cells and serves to anchor proteins to the cell surface. This gene encodes a mannosyltransferase, GPI-MT-I, that transfers the first mannose to GPI on the lumenal side of the endoplasmic reticulum. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | PIGM |
| Official Name | phosphatidylinositol glycan anchor biosynthesis class M [Source:HGNC Symbol;Acc:HGNC:18858] |
| Ensembl ID | ENSG00000143315 |
| Bio databases IDs | |
| Aliases | phosphatidylinositol glycan anchor biosynthesis class M, GPI mannosyltransferase 1, DPM:GlcN-(acyl-)PI mannosyltransferase, dol-P-Man dependent GPI mannosyltransferase |
| Synonyms | 4933437L05Rik, C920011G20RIK, GPI-MT-I, LOC103694910, phosphatidylinositol glycan anchor biosynthesis class M, phosphatidylinositol glycan anchor biosynthesis, class M |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PIGM often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- mannosyltransferase
- enzyme
- protein binding
- glycolipid mannosyltransferase
- dolichyl-phosphate-mannose-protein mannosyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PIGM gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- GPI anchor biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
Molecular Function
What the gene product does at the molecular level
- alpha-1,4-mannosyltransferase activity
- mannosyltransferase activity
- glycolipid mannosyltransferase activity