RAMP2 Gene Summary [Human]
The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP2) protein, CRLR functions as an adrenomedullin receptor. The RAMP2 protein is involved in core glycosylation and transportation of adrenomedullin receptor to the cell surface. [provided by RefSeq, Jul 2008]
Details
| Type | Processed Transcript |
| Official Symbol | RAMP2 |
| Official Name | receptor activity modifying protein 2 [Source:HGNC Symbol;Acc:HGNC:9844] |
| Ensembl ID | ENSG00000131477 |
| Bio databases IDs | |
| Aliases | receptor activity modifying protein 2 |
| Synonyms | receptor activity modifying protein 2, receptor (calcitonin) activity modifying protein 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RAMP2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- adrenomedullin receptor
- Receptor activity modifying family
- tail domain
- protein binding
- polypeptide hormone binding
- coreceptor
Pathways
Biological processes and signaling networks where the RAMP2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- impaired glucose tolerance
- bleeding
- obesity
- diabetic nephropathy
- non-insulin-dependent diabetes mellitus
- rheumatoid arthritis
- Klinefelter syndrome
- insulin-dependent diabetes mellitus
- edema
role in cell
- production in
- migration
- transmembrane potential
- binding in
- recruitment in
- adhesion
- size
- assembly
- binding
- calcium response in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- cellular membrane
- vesicles
- lysosome
- clathrin-coated pits
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RAMP2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein transport
- sprouting angiogenesis
- vasculogenesis
- intracellular protein transport
- positive regulation of angiogenesis
- heart development
- angiogenesis
- calcium ion transport
- negative regulation of endothelial cell apoptotic process
- G-protein coupled receptor signaling pathway
- regulation of G-protein coupled receptor protein signaling pathway
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- negative regulation of vascular permeability
- regulation of blood pressure
- vascular smooth muscle cell development
- positive regulation of gene expression
- positive regulation of vasculogenesis
- tight junction assembly
- basement membrane assembly
- cellular response to hormone stimulus
- cellular response to vascular endothelial growth factor stimulus
- adherens junction assembly
- receptor internalization
- protein localization in plasma membrane
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- coated pit
- receptor complex
- plasma membrane
- lysosome
- cell surface
Molecular Function
What the gene product does at the molecular level
- coreceptor activity
- protein binding
- adrenomedullin receptor activity