PI4KB Gene Summary [Human]
Enables 1-phosphatidylinositol 4-kinase activity and 14-3-3 protein binding activity. Predicted to be involved in phosphatidylinositol phosphate biosynthetic process and phosphatidylinositol-mediated signaling. Located in Golgi membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | PI4KB |
| Official Name | phosphatidylinositol 4-kinase beta [Source:HGNC Symbol;Acc:HGNC:8984] |
| Ensembl ID | ENSG00000143393 |
| Bio databases IDs | |
| Aliases | phosphatidylinositol 4-kinase beta |
| Synonyms | BB166060, DFNA87, ESTM41, NPIK, phosphatidylinositol 4-kinase beta, phosphatidylinositol 4-kinase β, PI4K 3 beta, PI4K 3 β, PI4K92, PI4K-BETA, PI4KIII, PI4KIIIB, PI4KIII beta, PI4KIII β, PI4K-β, PIK4CB |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PI4KB often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- 1-phosphatidylinositol 4-kinase
- kinase domain
- Phosphoinositide 3-kinase, catalytic domain
- Protein Kinases, catalytic domain
- Phosphatidylinositol 3- and 4-kinase
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- allergic rhinitis
- Waldenström macroglobulinemia
- autosomal dominant deafness type 87
- breast cancer
role in cell
- expression in
- growth
- cell death
- production in
- replication in
- quantity
- survival
- formation
- formation in
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- perinuclear region
- endosomes
- Golgi Apparatus
- cytosol
- endoplasmic reticulum membrane
- Golgi membrane
- mitochondrial outer membrane
- nuclear speckles
- endocytotic vesicle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PI4KB gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lysosome organization
- inner ear development
- phosphatidylinositol-mediated signaling
- signal transduction
- phosphatidylinositol phosphorylation
- phosphatidylinositol biosynthetic process
- receptor-mediated endocytosis
Cellular Component
Where in the cell the gene product is active
- rough endoplasmic reticulum membrane
- perinuclear region of cytoplasm
- endosome
- cytoplasm
- membrane
- cytosol
- Golgi membrane
- Golgi apparatus
- mitochondrial outer membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- 1-phosphatidylinositol 4-kinase activity
- 14-3-3 protein binding