PRKD1 Gene Summary [Human]
The protein encoded by this gene is a serine/threonine protein kinase involved in many cellular processes, including Golgi body membrane integrity and transport, cell migration and differentiation, MAPK8/JNK1 and Ras pathway signaling, MAPK1/3 (ERK1/2) pathway signaling, cell survival, and regulation of cell shape and adhesion. [provided by RefSeq, Jan 2017]
Details
| Type | Protein Coding |
| Official Symbol | PRKD1 |
| Official Name | protein kinase D1 [Source:HGNC Symbol;Acc:HGNC:9407] |
| Ensembl ID | ENSG00000184304 |
| Bio databases IDs | |
| Aliases | protein kinase D1 |
| Synonyms | CHDED, Kpcd1, nPKC-D1, nPKC-mu, PKCM, PKC-MU, PKD, PKD1, PRKCM, PRKD1 (protein kinase D1), protein kinase D1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PRKD1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- Kinase regulatory loop binding domain
- catalytic domain
- heat shock protein binding
- protein kinase C binding
- C1A domain
- Pleckstrin homology-like domain
- phosphoinositide 3-kinase regulator
- protein binding
- Protein kinase domain
- identical protein binding
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- diacylglycerol binding domain
- protein kinase C conserved region 1 (C1 domain) superfamily
- C1B domain
- protein kinase C
- PDZ binding motif
- Tyrosine kinase, catalytic domain
- cysteine rich domain
Pathways
Biological processes and signaling networks where the PRKD1 gene in human plays a role, providing insight into its function and relevance in health or disease.
- 14-3-3-mediated Signaling
- Apelin Endothelial Signaling Pathway
- CCR5 Signaling in Macrophages
- Cholecystokinin/Gastrin-mediated Signaling
- Corticotropin Releasing Hormone Signaling
- CXCR4 Signaling
- Docosahexaenoic Acid (DHA) Signaling
- eNOS Signaling
- ErbB4 Signaling
- fMLP Signaling in Neutrophils
- Growth Hormone Signaling
- Gαq Signaling
- HER-2 Signaling in Breast Cancer
- HGF Signaling
- IL-3 Signaling
- Macropinocytosis Signaling
- Mechanisms of Viral Exit from Host Cells
- Neuropathic Pain Signaling In Dorsal Horn Neurons
- NF-κB Activation by Viruses
- nNOS Signaling in Neurons
- Prolactin Signaling
- Thrombopoietin Signaling
- UVB-Induced MAPK Signaling
- UVC-Induced MAPK Signaling
- VDR/RXR Activation
- VEGF Family Ligand-Receptor Interactions
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- epithelial cancer
- bipolar disorder
- cervical cancer
- pancreatic ductal adenocarcinoma
- pancreatic epithelial cancer
- ductal pancreatic cancer
- dementia
- coronary artery disease
- schizophrenia
regulated by
- TNF
- arachidonic acid
- hydrogen peroxide
- group B streptococcus serotype 1a Indian isolate
- D-glucose
- tetradecanoylphorbol acetate
- bombesin
- resveratrol
- FSH
- nocodazole
role in cell
- activation in
- expression in
- proliferation
- phosphorylation in
- morphology
- survival
- apoptosis
- cell death
- synthesis in
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- invadopodia
- perijunctional region
- perinuclear region
- cellular membrane
- cell cortex
- Nucleus
- Plasma Membrane
- Golgi Apparatus
- Mitochondria
- intercellular junctions
- cytosol
- membrane ruffles
- trans Golgi network
- perinuclear space
- Z line
- autophagic vacuoles
- membrane rafts
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PRKD1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of endocytosis
- cellular response to amino acid starvation
- protein autophosphorylation
- positive regulation of NF-kappaB transcription factor activity
- positive regulation of angiogenesis
- inflammatory response
- apoptotic process
- positive regulation of neuron projection development
- intracellular signal transduction
- sphingolipid biosynthetic process
- positive regulation of peptidyl-serine phosphorylation
- positive regulation of protein import into nucleus
- positive regulation of protein export from nucleus
- positive regulation of NLRP3 inflammasome complex assembly
- positive regulation of autophagy
- vascular endothelial growth factor receptor signaling pathway
- positive regulation of gene expression
- cellular response to hydroperoxide
- peptidyl-serine phosphorylation
- peptidyl-threonine phosphorylation
- positive regulation of protein kinase B signaling cascade
- Golgi organization
- positive regulation of peptide hormone secretion
- nervous system development
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of osteoblast differentiation
- integrin-mediated signaling pathway
- positive regulation of cell size
- angiogenesis
- regulation of keratinocyte proliferation
- positive regulation of endothelial cell chemotaxis
- cellular response to norepinephrine stimulus
- positive regulation of endothelial cell migration
- positive regulation of sarcomere organization
- regulation of integrin-mediated signaling pathway
- defense response to Gram-negative bacterium
- signal transduction
- phospholipase C-activating G-protein coupled receptor signaling pathway
- positive regulation of blood vessel endothelial cell migration
- regulation of release of sequestered calcium ion into cytosol
- innate immune response
- cell differentiation
- cellular response to oxidative stress
- positive regulation of endothelial cell proliferation
- cellular response to vascular endothelial growth factor stimulus
- regulation of skeletal muscle contraction by modulation of calcium ion sensitivity of myofibril
- Golgi vesicle transport
Cellular Component
Where in the cell the gene product is active
- Z disc
- nucleus
- trans-Golgi network
- perinuclear region of cytoplasm
- cell-cell junction
- cell cortex
- cytosol
- Golgi apparatus
- autophagic vacuole membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein kinase C binding
- heat shock protein binding
- ATP binding
- identical protein binding
- protein binding
- metal ion binding
- protein serine/threonine kinase activity
- kinase activity
- protein kinase C activity