MALL Gene Summary [Human]
This gene encodes an element of the machinery for raft-mediated trafficking in endothelial cells. The encoded protein, a member of the MAL proteolipid family, predominantly localizes in glycolipid- and cholesterol-enriched membrane (GEM) rafts. It interacts with caveolin-1. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | MALL |
| Official Name | mal, T cell differentiation protein like [Source:HGNC Symbol;Acc:HGNC:6818] |
| Ensembl ID | ENSG00000144063 |
| Bio databases IDs | |
| Aliases | mal, T cell differentiation protein like |
| Synonyms | BENE, mal, T-cell differentiation protein-like, RGD1310869 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MALL often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Membrane-associating domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- cell periphery
- perinuclear region
- intracellular membranes
- cellular membrane
- Plasma Membrane
- Golgi membrane
- cytoplasmic vesicles
- membrane rafts
- clathrin-coated vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MALL gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- myelination
- cholesterol homeostasis
Cellular Component
Where in the cell the gene product is active
- membrane raft
- membrane
- cytoplasmic vesicle
- Golgi membrane
- clathrin-coated vesicle
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- structural constituent of myelin sheath