PLA2G2E Gene Summary [Human]
Enables calcium ion binding activity and calcium-dependent phospholipase A2 activity. Predicted to be involved in phospholipid metabolic process. Predicted to act upstream of or within low-density lipoprotein particle remodeling. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | PLA2G2E |
| Official Name | phospholipase A2 group IIE [Source:HGNC Symbol;Acc:HGNC:13414] |
| Ensembl ID | ENSG00000188784 |
| Bio databases IDs | |
| Aliases | phospholipase A2 group IIE |
| Synonyms | GIIE sPLA2, phospholipase A2 group IIE, phospholipase A2, group IIE, sPLA2-IIE |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PLA2G2E often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- calcium-dependent phospholipase A2
- calcium ion binding
- enzyme
- protein binding
- phospholipase A2
- PLA2_like
Pathways
Biological processes and signaling networks where the PLA2G2E gene in human plays a role, providing insight into its function and relevance in health or disease.
- Antioxidant Action of Vitamin C
- Atherosclerosis Signaling
- CCR3 Signaling in Eosinophils
- Docosahexaenoic Acid (DHA) Signaling
- Eicosanoid Signaling
- Endothelin-1 Signaling
- ERK/MAPK Signaling
- Fc Epsilon RI Signaling
- Glucocorticoid Receptor Signaling
- MIF Regulation of Innate Immunity
- MIF-mediated Glucocorticoid Regulation
- Neuroinflammation Signaling Pathway
- p38 MAPK Signaling
- Phagosome Formation
- Role of MAPK Signaling in the Pathogenesis of Influenza
- Serotonin Receptor Signaling
- Sperm Motility
- VEGF Family Ligand-Receptor Interactions
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetic nephropathy
- cardiac fibrosis
- Huntington disease
- morbid obesity
regulated by
- lipopolysaccharide
- BB0603
- indoxam
- POU4F2
- Borrelia burgdorferi strain HB19
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PLA2G2E gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- phosphatidylglycerol metabolic process
- inflammatory response
- phosphatidylcholine metabolic process
- arachidonic acid secretion
- negative regulation of T cell proliferation
- low-density lipoprotein particle remodeling
- lipid catabolic process
- phospholipid metabolic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- extracellular region
Molecular Function
What the gene product does at the molecular level
- phospholipase A2 activity
- protein binding
- calcium-dependent phospholipase A2 activity
- calcium ion binding
- phospholipid binding