UBR3 Gene Summary [Human]
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in several processes, including cellular protein metabolic process; sensory perception of smell; and suckling behavior. Predicted to act upstream of or within in utero embryonic development and olfactory behavior. Predicted to be integral component of membrane. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | UBR3 |
| Official Name | ubiquitin protein ligase E3 component n-recognin 3 [Source:HGNC Symbol;Acc:HGNC:30467] |
| Ensembl ID | ENSG00000144357 |
| Bio databases IDs | |
| Aliases | ubiquitin protein ligase E3 component n-recognin 3 |
| Synonyms | 1110059H15RIK, 4833421P10Rik, A130030D10, A130030D10Rik, AU016126, KIAA2024, RGD1565257, ubiquitin protein ligase E3 component n-recognin 3, Zfp650, ZNF650 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human UBR3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Putative zinc finger in N-recognin (UBR box)
- Putative zinc finger in N-recognin
- ubiquitin protein ligase activity
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- ubiquitin-protein transferase activity
- UBR-box
- enzyme
- protein binding
- Proteolysis_6 C-terminal
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human UBR3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ubiquitin-dependent protein catabolic process via the N-end rule pathway
- in utero embryonic development
- embryo development ending in birth or egg hatching
- suckling behavior
- sensory perception of smell
- positive regulation of protein catabolic process
- olfactory behavior
- protein ubiquitination
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- ubiquitin ligase complex
- cytoplasm
- membrane
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- zinc ion binding