NMU Gene Summary [Human]
This gene encodes a member of the neuromedin family of neuropeptides. The encoded protein is a precursor that is proteolytically processed to generate a biologically active neuropeptide that plays a role in pain, stress, immune-mediated inflammatory diseases and feeding regulation. Increased expression of this gene was observed in renal, pancreatic and lung cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. Some of these isoforms may undergo similar processing to generate the mature peptide. [provided by RefSeq, Jul 2015]
Details
| Type | Protein Coding |
| Official Symbol | NMU |
| Official Name | neuromedin U [Source:HGNC Symbol;Acc:HGNC:7859] |
| Ensembl ID | ENSG00000109255 |
| Bio databases IDs | |
| Aliases | neuromedin U, prepro-NMU |
| Synonyms | neuromedin U, NMU-23, NMU25, Nmu-r1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NMU often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- neuromedin U receptor binding
- protein binding
- receptor binding
- Neuromedin U
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- edema
- ulcerative colitis
- endometrial adenocarcinoma
- endometrial adenocarcinoma formation
- arthritis
- hyperphagia
- urothelial bladder carcinoma
- transitional cell bladder cancer
- albuminuria
role in cell
- expression in
- migration
- activation in
- growth
- phosphorylation in
- production in
- number
- cellular infiltration by
- quantity
- degranulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- axon terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NMU gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuropeptide signaling pathway
- G-protein coupled receptor signaling pathway
- temperature homeostasis
- positive regulation of synaptic transmission
- energy homeostasis
- regulation of grooming behavior
- regulation of feeding behavior
- positive regulation of smooth muscle contraction
Cellular Component
Where in the cell the gene product is active
- terminal button
- extracellular region
Molecular Function
What the gene product does at the molecular level
- neuromedin U receptor binding
- protein binding
- type 1 neuromedin U receptor binding
- receptor binding
- type 2 neuromedin U receptor binding