UBE2B Gene Summary [Human]
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Its protein sequence is 100% identical to the mouse, rat, and rabbit homologs, which indicates that this enzyme is highly conserved in eukaryotic evolution. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | UBE2B |
| Official Name | ubiquitin conjugating enzyme E2 B [Source:HGNC Symbol;Acc:HGNC:12473] |
| Ensembl ID | ENSG00000119048 |
| Bio databases IDs | |
| Aliases | ubiquitin conjugating enzyme E2 B |
| Synonyms | 17-kDa Ubiquitin-Conjugating Enzyme E2, 2610301N02RIK, E2 14K, E2-17kDa, E2b, HHR6B, HR6B, LOC103694902, LOC81816, mHR6B, RAD6B, UBC2, ubiquitin-conjugating enzyme E2B |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human UBE2B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- Ubiquitin-conjugating enzyme
- ubiquitin conjugating enzyme
- ubiquitin-protein transferase activity
- UBCc_UEV
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the UBE2B gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- uterine leiomyoma
- leiomyomatosis
- teratozoospermia
- systemic lupus erythematosus
- congenital heart disease
- oligozoospermia
- asthenozoospermia
- adenomyosis
- infection by HIV-1
role in cell
- apoptosis
- cell death
- growth
- quantity
- abnormal morphology
- organization
- arrangement
- formation
- fusion
- cisplatin resistance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Plasma Membrane
- nucleoplasm
- sex chromatin
- chromatin
- replication fork
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human UBE2B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- response to UV
- negative regulation of developmental process
- response to xenobiotic stimulus
- chromatin organization
- postreplication repair
- chiasma assembly
- in utero embryonic development
- apoptotic process
- protein autoubiquitination
- protein K11-linked ubiquitination
- germ cell programmed cell death
- protein K48-linked ubiquitination
- protein polyubiquitination
- spermatogenesis
- positive regulation of canonical Wnt receptor signaling pathway
- sperm axoneme assembly
- response to DNA damage stimulus
- negative regulation of cAMP-mediated signaling
- ubiquitin-dependent protein catabolic process
- meiotic telomere clustering
- synaptonemal complex organization
- proteasomal ubiquitin-dependent protein catabolic process
- positive regulation of reciprocal meiotic recombination
- negative regulation of apoptotic process
- protein K63-linked ubiquitination
- negative regulation of reproductive process
- protein stabilization
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- replication fork
- XY body
- nucleus
- cytoplasm
- chromatin
- HULC complex
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- ATP binding
- ubiquitin protein ligase binding
- protein binding