GLRA3 Gene Summary [Human]
This gene encodes a member of the ligand-gated ion channel protein family. The encoded protein is a member of the glycine receptor subfamily. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]
Details
| Type | Protein Coding |
| Official Symbol | GLRA3 |
| Official Name | glycine receptor alpha 3 [Source:HGNC Symbol;Acc:HGNC:4328] |
| Ensembl ID | ENSG00000145451 |
| Bio databases IDs | |
| Aliases | glycine receptor alpha 3 |
| Synonyms | glycine receptor alpha 3, glycine receptor, alpha 3, glycine receptor, alpha 3 subunit, glycine receptor α 3, glycine receptor, α 3, glycine receptor, α 3 subunit, LOC100909864 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GLRA3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transmembrane domain of Cys-loop neurotransmitter-gated ion channels
- channel/pore class transporter
- extracellular ligand-gated ion channel
- Cation transporter family protein
- protein binding
- ion channel
- anion channel
- neurotransmitter receptor
- LGIC_ECD
- Neurotransmitter-gated ion-channel transmembrane region
- Neurotransmitter-gated ion-channel ligand binding domain
- chloride channel
- ligand-gated ion channel
- glycine-gated chloride channel
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular membrane-bounded organelle
- cellular membrane
- presynaptic membrane
- synaptic membrane
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GLRA3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of excitatory postsynaptic membrane potential
- regulation of membrane potential
- protein homooligomerization
- synaptic transmission
Cellular Component
Where in the cell the gene product is active
- dendrite
- glycine-gated chloride channel complex
- postsynaptic membrane
- intracellular membrane-bounded organelle
- synapse
- perikaryon
- neuron projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- extracellular-glycine-gated chloride channel activity
- transmembrane signaling receptor activity
- metal ion binding
- excitatory extracellular ligand-gated ion channel activity
- neurotransmitter receptor activity
- glycine binding
- chloride channel activity
- glycine-gated chloride ion channel activity