GCNT3 Gene Summary [Human]
This gene encodes a member of the N-acetylglucosaminyltransferase family. The encoded protein is a beta-6-N-acetylglucosamine-transferase that catalyzes the formation of core 2 and core 4 O-glycans on mucin-type glycoproteins.[provided by RefSeq, Apr 2009]
Details
| Type | Processed Transcript |
| Official Symbol | GCNT3 |
| Official Name | glucosaminyl (N-acetyl) transferase 3, mucin type [Source:HGNC Symbol;Acc:HGNC:4205] |
| Ensembl ID | ENSG00000140297 |
| Bio databases IDs | |
| Aliases | glucosaminyl (N-acetyl) transferase 3, mucin type |
| Synonyms | 2010013H22RIK, 2210021I22RIK, 2210401J11RIK, C24GNT, C2/4GnT, C2GNT2, C2GNTM, DI/C2/C4GNT, dIGnT, glucosaminyl (N-acetyl) transferase 3, mucin type, GNTM |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GCNT3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Core-2/I-Branching enzyme
- acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
- N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase
- beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
- acetylglucosaminyltransferase
- enzyme
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- organismal death
- colitis
regulates
- Ighg2b
- core 2 O-glycans
- IgA
- core 4 O-glycan
- Immunoglobulin
- core 2 oligosaccharide
- O-glycan
- IgG2b
- I-branching core 1 O-glycan
- IgG1
role in cell
- proliferation
- sphere formation
- apigenin sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GCNT3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- carbohydrate metabolic process
- intestinal absorption
- tissue morphogenesis
- kidney morphogenesis
- protein O-linked glycosylation
- O-glycan processing
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- membrane
- Golgi membrane
Molecular Function
What the gene product does at the molecular level
- N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity
- acetylglucosaminyltransferase activity
- beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity