IK Gene Summary [Human]
The protein encoded by this gene was identified by its RED repeat, a stretch of repeated arginine, glutamic acid and aspartic acid residues. The protein localizes to discrete dots within the nucleus, excluding the nucleolus. Its function is unknown. This gene maps to chromosome 5; however, a pseudogene may exist on chromosome 2. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | IK |
| Official Name | IK cytokine [Source:HGNC Symbol;Acc:HGNC:5958] |
| Ensembl ID | ENSG00000113141 |
| Bio databases IDs | |
| Aliases | IK cytokine |
| Synonyms | CSA2, IFN gamma ANTAGONIST, IFN gamma ANTAGONIST CYTOKINE, IFN γ ANTAGONIST, IFN γ ANTAGONIST CYTOKINE, IK cytokine, IK factor, MuRED, RED, RER |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IK often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RED-like protein C-terminal region
- RED-like protein N-terminal region
- protein binding
- cytokine
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
role in cell
- cell viability
- colony formation
- splicing by
- alternative splicing in
- integration in
- integration
- spindle checkpoint in
- mitosis
- homologous recombination in
- spindle checkpoint
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- Nucleus
- spliceosomes
- chromosome
- nucleoplasm
- spindle pole
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IK gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitotic cell cycle spindle assembly checkpoint
- protein localization to kinetochore
- mitotic cell cycle
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nuclear speck
- nuclear chromosome
- U2-type precatalytic spliceosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding